Tesamorelin is a synthetic analog of Growth Hormone–Releasing Hormone (GHRH), designed to stimulate the pituitary gland to produce and release natural growth hormone (GH). Its mechanism involves binding to GHRH receptors on the pituitary, which stimulates the pulsatile release of endogenous GH. The compound features enhanced stability compared to natural GHRH due to a modification: a N-terminal fatty acid group, which contributes to its long-lasting effect and efficacy in conditions like HIV-associated lipodystrophy.